Journal article
Parental Prepuberty Overweight and Offspring Lung Function
M Lønnebotn, L Calciano, A Johannessen, DL Jarvis, MJ Abramson, B Benediktsdóttir, L Bråbäck, KA Franklin, R Godoy, M Holm, C Janson, NO Jõgi, J Kirkeleit, A Malinovschi, A Pereira-Vega, V Schlünssen, SC Dharmage, S Accordini, FG Real, C Svanes
Nutrients | MDPI | Published : 2022
DOI: 10.3390/nu14071506
Abstract
In a recent study we found that fathers’ but not mothers’ onset of overweight in puberty was associated with asthma in adult offspring. The potential impact on offspring’s adult lung function, a key marker of general and respiratory health, has not been studied. We investigated the potential causal effects of parents’ overweight on adult offspring’s lung function within the paternal and maternal lines. We included 929 offspring (aged 18–54, 54% daughters) of 308 fathers and 388 mothers (aged 40–66). Counterfactual-based multi-group mediation analyses by offspring’s sex (potential moderator) were used, with offspring’s prepubertal overweight and/or adult height as potential mediators. Unknown..
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Awarded by Norges Astma- og Allergiforbund
Funding Acknowledgements
The coordination and establishment of the RHINESSA study have received funding from the Research Council of Norway (Grants No. 274767, 214123, 228174, 230827 and 273838), ERC StG project BRuSH #804199, the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633212 (the ALEC Study WP2), the Bergen Medical Research Foundation, and the Western Norwegian Regional Health Authorities (Grants No. 912011, 911892 and 911631). Study centres have further received local funding from the following: Bergen: the above grants, World University Network (REF and Sustainability grants), Norwegian Labour Inspection and the Norwegian Asthma and Allergy Association. Albacete and Huelva: Sociedad Espanola de Patologia Respiratoria (SEPAR) Fondo de Investigacion Sanitaria (FIS PS09). Goteborg, Umea and Uppsala: the Swedish Heart and Lung Foundation, the Swedish Asthma and Allergy Association. Reykjavik: Iceland University. Melbourne: NHMRC Project Grant ID1128450, Melbourne University. Tartu: the Estonian Research Council (Grant No. PUT562). Arhus: The Danish Wood Foundation (Grant No. 444508795), the Danish Working Environment Authority (Grant No. 20150067134), Aarhus University (PhD scholarship). The RHINE study has received funding from the Danish Lung Association, Estonian Science Foundation, Icelandic Research Council, Norwegian Research Council, Norwegian Asthma and Allergy Association, Swedish Asthma and Allergy Association, Swedish Heart and Lung Foundation and Vardal Foundation for Health Care Science and Allergy Research. The coordination of the ECRHS has been supported by the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633212 (the ALEC study) and the Medical Research Council (ECRHS III). Local funding agencies for ECRHS III are reported in the online supplementary material. The funding agencies have had no direct role in the conduct of the study or the data collection and management, nor in data analysis or manuscript preparation.